Verdinexor

What is verdinexor?

Verdinexor (Laverdia®-CA1) is a chemotherapy (anticancer) agent used to slow the growth and spread of lymphoma in dogs.

It is conditionally approved for veterinary use in dogs with lymphoma by the FDA in the United States; any off-label use is not permitted.

How do I give my pet verdinexor?

• Verdinexor comes in tablet form.
• Tablets are given orally (by mouth).
• This medication must be given immediately after feeding.
• Ensure your dog swallows the entire tablet.
• Do not crush or split the tablet.
• Give this medication exactly as prescribed and directed by your veterinarian.
• Wear gloves for 3 days after each dose when handling your dog’s bodily fluids and waste, food and water dishes, and toys.

Verdinexor is considered a hazardous drug, so it is essential to avoid accidental exposure. Wear chemotherapy-resistant gloves when handling the medication, and do not handle if you are pregnant or nursing. If your pet vomits after giving this drug, wear gloves while cleaning up.

This medication will take effect within 1–5 hours, though outward effects may not be immediately noticeable.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Verdinexor may cause the following side effects:

• Mild lack of appetite or energy
• Mild nausea or vomiting, diarrhea
• Increased thirst or urination
• Excessive shedding

Serious adverse reactions may occur. If any of the following signs develop, stop giving verdinexor and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• Persistent vomiting or diarrhea, lack of appetite for more than 1 day,
• Signs of bone marrow suppression (e.g., persistent weakness, unexplained bruising or bleeding, fever)
• Coughing or difficulty breathing
• Tremors, seizures, or disorientation

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This moderate-acting medication should stop working within days to weeks, though effects may last longer in pets with kidney and/or liver disease.

Are there any risk factors for this medication?

DO NOT USE in dogs that:

• Are allergic to any component of the medication
• Are pregnant, nursing, or used for breeding (including males)
• Weigh less than 19.8 lb (9 kg)
• Do not have a confirmed diagnosis of lymphoma

USE WITH CAUTION in dogs that:

• Are younger than 7 months of age
• Have kidney disease, liver disease, diabetes mellitus, heart disease, severe infections, and/or elevated blood calcium levels
• Are receiving other chemotherapy agents and/or have other tumor types in addition to lymphoma

Are there any drug interactions I should be aware of?

The following medications should be used with caution when given with verdinexor:

• Acetaminophen
• Cisplatin
• Cyclophosphamide
• Doxorubicin
• Mitoxantrone
• Spinosad

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Baseline and periodic blood tests as recommended by your veterinarian (complete blood count, biochemistry).
• Baseline and periodic urine tests as recommended by your veterinarian.
• At home, monitor for any side effects such as those noted above. If any occur, stop using the medication and contact your veterinarian.

How do I store verdinexor?

• Store in a tightly sealed container at room temperature of 68°F-77°F (20°C–25°C), protected from light.
• Store away from other medications, food, and food preparation areas.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.