Cetyl Myristoleate

What is cetyl myristoleate?

Cetyl myristoleate is a type of fatty acid. It is a supplement used to treat the pain, decreased range of motion, and mobility consequences of osteoarthritis in dogs. Its mechanism of action on the body is unknown, but it may be like that of omega-3 fatty acids.

The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before they are sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately. The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer. These products are not tested by Health Canada. 

Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy.

Although the information in this handout may be helpful, it also may be incomplete and may not represent the full range of effects the supplement could have on your pet.

How is cetyl myristoleate given?

• Cetyl myristoleate comes in capsule, tablet, and cream forms.
• Capsules and tablets are given orally (by mouth). Creams are applied topically directly to the skin.
• The oral forms may be given with or without food.
• Follow your veterinarian’s instructions on administering this medication and give for the entire time recommended by your veterinarian, even if your pet starts to feel better.

This medication should take effect within 1–2 days; however, outward effects may not be immediately noticeable.

What if I miss giving my pet the supplement?

If you miss a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Cetyl myristoleate may cause the following side effects:

• Mild gastrointestinal upset

Serious adverse reactions may occur. If any of the following signs develop, stop giving cetyl myristoleate and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 1–2 days, although effects may last longer in pets with kidney and/or liver disease.

Are there any risk factors for this supplement?

DO NOT USE cetyl myristoleate in:

• Pets that are allergic to any component of this medication

USE WITH CAUTION in:

• Pets that are pregnant or nursing
• Pets that are debilitated
• Pets that are young

Are there any drug interactions I should be aware of?

There are no known drug interactions with cetyl myristoleate. Vitamins, herbal therapies, and supplements have the potential to interact with each other, as well as with prescription and over-the-counter medications. Be sure to tell your veterinarian about any medications (including all vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this supplement?

• Follow your veterinarian’s directions for follow-up visits and diagnostics.
• At home, monitor for any abnormal changes. If any occur, discontinue the medication and contact your veterinarian.

How do I store cetyl myristoleate?

• Store the medication at room temperature.
• Protect from light and moisture.
• Keep the container out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms. Report any adverse effects to the FDA or Health Canada.